Abstract: Objective〓〖WT5”BZ〗To investigate the relationship between thyroid hormones and the detection〖JP〗 rate of chronic kidney disease(CKD) in hospitalized patients with type 2 diabetes mellitus(T2DM).〖WT5”HZ〗Methods〓〖WT5”BZ〗A total of 1118 T2DM patients were included in our department.All  patients were divided into CKD group and nonchronic kidney disease(NCKD) group according to whether accompanied with CKD.General and clinical data of the two groups were collected and compared.Multivariate logistic regression analysis was used to study the risk factors related to CKD.〖WT5”HZ〗Results〓〖WT5”BZ〗The detection rate of CKD in T2DM+hypertension(HP) patients was higher than that in T2DM patients（P<0.001）.The age,course of HP,course of T2DM,systolic blood pressure,diastolic blood pressure and the level of thyrotrophin(TSH) in CKD group were higher than those in NCKD group，the level of fasting glucose(FPG),glycosylated hemoglobin(HbA1c),triiodinated thyroxine (TT3),free thyroxine(TT4),free triiodinated thyroxine (FT3) and free thyroxine (FT4) were lower than those in NCKD group（P<0.05）.Multivariate logistic regression analysis showed that the level of FT3,course of T2DM,FPG,lowdensity lipoprotein（LDLC）,systolic blood pressure were independently related to proteinuria accompanied estimated glomerular rate(eGFR) decrease，the level of FT3,gender and systolic blood pressure were independently related to proteinuria，the level of TT4，FT3，the course of T2DM,age,LDLC and diastolic blood pressure were independently related to eGFR decrease，FT3 was an independent risk factor for proteinuria,eGFR decrease and proteinuria with eGFR decrease.〖WT5”HZ〗Conclusion〓〖WT5”BZ〗The levels of thyroid hormone in T2DM patients with CKD are different from those in T2DM patients.FT3 is an independent risk factor for proteinuria,eGFR decrease,and proteinuria with eGFR decrease,it may affect the detection rate of CKD.

Key words: Diabetes mellitus, Chronic kidney disease, Detection rate, Thyroid hormone