关键词: 脓毒症; 糖尿病; 主要不良心血管事件; 全因死亡

Abstract: Objective To investigate the characteristics of major adverse cardiovascular events(MACE) and the risk of all-cause mortality in patients with diabetes mellitus and sepsis within 30 days of hospitalization.Methods A total of 720 patients with sepsis were enrolled.According to whether or not with diabetes mellitus,the patients were divided into diabetic group（n=252） and non-diabetic group（n=468）.The occurrence of MACE and all-cause mortality as well as the characteristics of MACE occurred on the 1st to 15th day(D₁₅) and the 16th to 30th day(D₃₀) were compared between the two groups.Results The incidence of MACE in the diabetic group was 36.5%,which was higher than that in non-diabetic group(22.2%，P<0.05),but there was no statistical difference in the incidence of acute cerebrovascular accidents between the two groups（P＞0.05）.The incidence of all-cause death in patients with diabetes was 25.0%,which was higher than that in non-diabetic group（15.6%，P<0.05).The incidences of ACS,acute heart failure,severe arrhythmia and cardiogenic death in D₁₅ of the two groups were respectively higher than those of D₃₀ in the same groups(P<0.05),but there was no statistical difference in the incidence of acute cerebrovascular accidents between D₁₅ and D₃₀ in both two groups（P＞0.05）.Multivariate logistic regression analysis showed that diabetes was an independent predictor of MACE(P<0.05).Conclusion In patients with diabetes mellitus and sepsis,the incidence of MACE and all-cause death during the 30day hospital stay increases significantly.Effective control of blood glucose may reduce MACE and all-cause mortality in sepsis patients with diabetes mellitus.

Key words: Sepsis; Diabetes mellitus; Major adverse cardiovascular events; All cause mortality