关键词: 微小RNA-20a; 自噬相关基因7; 急性ST段抬高型心肌梗死; 经皮冠状动脉介入治疗; 主要不良心血管事件

Abstract: Objective To explore predictive value of serum microRNA(miR)-20a and autophagy related gene 7(ATG7) on major adverse cardiovascular event(MACE) in patients with acute ST-segment elevation myocardial infarction(STEMI) after percutaneous coronary intervention(PCI).Methods According to in-hospital prognosis,233 patients with newly diagnosed acute STEMI undergoing PCI were divided into MACE group(64 cases) and non-MACE group(169 cases).Serum amino terminal pro-brain natriuretic peptide(NT-proBNP),type Ⅲ procollagen amino terminal peptide(PⅢNP),ATG7 and miR-20a levels were compared and to analyze their correlation.Results Age,NT-proBNP,PⅢNP,ATG7 levels and ratio of patients with Killip cardiac function grade Ⅳ in MACE group were higher than those in non-MACE group,while serum miR-20a level was lower than that in non-MACE group(P<0.05).Multivariate logistic regression analysis showed that elevated age,Killip cardiac function grade Ⅳ,NT-proBNP,PⅢNP and ATG7 levels were independent risk factors for in-hospital MACE after PCI in patients with acute STEMI,and elevated serum miR-20a level was an independent protective factor for it（P<0.05).Pearson correlation analysis showed that serum miR-20a was negatively correlated with ATG7,NT-proBNP and PⅢNP(P<0.05)，while serum ATG7 was positively correlated with NT-proBNP and PⅢNP（P<0.05).Receiver operating characteristic(ROC) curve analysis showed that value of serum miR-20a combined with ATG7 predicted in-hospital MACE in patients with acute STEMI after PCI was higher than serum miR-20a and ATG7.Conclusion Serum miR-20a and ATG7 are closely related with NT-proBNP and PⅢNP and are independent predictive factors of in-hospital MACE in patients with acute STEMI after PCI.

Key words: MicroRNA20a; Autophagy related gene 7; Acute STsegment elevation myocardial infarction; Percutaneous coronary intervention; Major adverse cardiovascular event