关键词: 人免疫缺陷病毒; 艾滋病; 分枝杆菌; 结核分枝杆菌; 非结核分枝杆菌

Abstract: Objective To analyze the distribution and drug resistance of mycobacterium tuberculosis(MTB) and non-tuberculosis mycobacteriu(NTM) among AIDS patients with positive results of mycobacterium culture in Shanghai public health clinical center from 2006 to 2015.Methods From January 2006 to December 2015,the patients who were admitted to our hospital with clinical symptoms and positive results of mycobacterium culture were collected.The general data such as age and gender,the results of subsequent drug resistance test and NTM typing results were collected and analyzed.Results In 816 cases with mycobacterium,679 cases were male and 137 cases were female.The median age was 40 years.There were 364 patients(44.6%) infected with MTB and 377 patients(46.2%) with NTM.There were 275 cases with MTB infection and drug resistance test data.The drug resistance rates to streptomycin and isoniazid were 24.0%(66 cases) respectively,the drup resistance rate to ethambutol was 17.1%(47 cases),and the drug resistance rate to rifampicin was 16.7%( 46 cases);42 cases(15.3%) were multi-drug resistant tuberculosis.There were 124 patients with NTM infection and drug resistance test data.The resistance rate to isoniazid was 91.1%(113 cases),and the resistance rate to streptomycin was 83.9%(104 cases).The drug resistance rate to rifampicin was 47.6%(59 cases),and the drug resistance rate to ethambutol was 38.7%(48 cases).A total of 102 NTM typing data were collected,including 33 cases(32.3%) of mycobacterium avium,29 cases(28.4%) of mycobacterium Gordon and 25 cases(24.5%) of mycobacterium Kansas.Conclusion For AIDS patients with mycobacterium infection,the proportion of NTM is significantly higher than that of the general population without HIV infection,so it is necessary to adjust the regimen according to the results of drug sensitivity test.

Key words: Human Immunodeficiency Virus; Acquired immunodeficiency syndrome; Mycobacterium; Mycobacterium tuberculosis; Nontuberculosis Mycobacteria